[s2e8] Let It Be May 2026

: Cristina Yang and Preston Burke attempt their first "normal" date outside the hospital. The evening is saved from total awkwardness only when they must work together to save a man having a heart attack in the restaurant. Cast & Crew

The primary conflict revolves around Savannah and Weiss, a married couple from New York. Savannah, having lost several female relatives to cancer, seeks a preemptive double mastectomy and hysterectomy despite not currently having the disease. This request causes significant discord, as Weiss struggles to support the decision, while Addison and Derek find their own strained marriage further tested by the case. Key Medical Cases & Subplots [S2E8] Let It Be

: Approximately 43 minutes (excluding commercials) : Cristina Yang and Preston Burke attempt their

: Primarily at the Veterans Hospital in North Hills, CA, which doubles for Seattle Grace. Savannah, having lost several female relatives to cancer,

Directed by and written by Mimi Schmir , the episode features the series' core ensemble alongside notable guest stars. Ellen Pompeo as Meredith Grey Patrick Dempsey as Derek Shepherd Sandra Oh as Cristina Yang Katherine Heigl as Izzie Stevens Chandra Wilson as Miranda Bailey Guest Stars Arija Bareikis as Savannah Joseph Lyle Taylor as Weiss Shelley Berman as Jed Sorento Production Details Original Air Date : November 13, 2005 Network : ABC

The episode is generally viewed as a solid mid-season entry, praised by fans for its "balanced mixed bag of drama and comedy". While some viewers found the Savannah and Weiss plot frustrating due to the husband's lack of support for her health decision, others noted the episode effectively highlighted the developing dynamics between characters like Bailey and Webber.