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After a period of tension, Alex and Jo begin to reconcile, sharing a passionate moment in a hospital elevator.

Meredith treats a patient from her past, a therapist who develops a medically impossible 24-inch blood clot. Their conversations lead Meredith to realize she is projecting her anger about Nathan Riggs' situation—specifically that he got his "lost love" (Megan Hunt) back while she never will.

Amelia initially keeps the diagnosis a secret from her husband, Owen, and her colleagues, struggling with an identity crisis as she wonders how much of her personality was actually the tumor.

The ER treats a young man named Pete who was injured in a hot air balloon accident during an elaborate "homecoming proposal" gone wrong. Relationship Developments

The most significant storyline involves , who discovers she has a massive brain tumor that has been growing for nearly ten years.

Richard Webber later shows her a scan of his own past tumor to offer support, only for Amelia to point out that her own is significantly larger. Medical Cases and Conflict