Episode 22: Resignation May 2026

is the 22nd episode of the third season of House, M.D. (Season 3, Episode 22). It originally aired on May 8, 2007, on FOX. Episode Overview

: House suspects Dr. Wilson is depressed and sluggish. In a classic "House" move, he spikes Wilson’s coffee with amphetamines (speed) to "help" him, leading to Wilson being hyperactive and jittery throughout the episode. Cast and Credits Director : Martha Mitchell. Writer : Pamela Davis. Guest Star : Piper Perabo plays the patient, Honey. Where to Watch Episode 22: Resignation

: A 19-year-old college student and karate practitioner suddenly coughs up blood during a workout. After numerous tests fail to explain her declining health, it is revealed she attempted suicide by ingesting a specific cleaner, which caused a bacterial infection. is the 22nd episode of the third season of House, M