: House treats them as a single organism with three different "outputs." He theorizes that while their DNA is the same, their epigenetics —how those genes are expressed—have diverged due to secret lifestyle differences.
The breakthrough comes when Chloe, the "healthy" one, finally collapses. House realizes the common denominator isn't what they are doing , but what they are taking . The Diagnosis: Dr. House: 2Г—3
: Cuddy pressures House to find a solution before Maya’s lungs fail completely. Meanwhile, House is distracted by Wilson, who has started "triplet-dating" (dating a woman who is also a triplet), leading to a series of pranks about identity and individuality. The "Eureka" Moment : House treats them as a single organism
House discovers that the sisters were all taking a specific "natural" performance-enhancing supplement to stay thin for gymnastics. Because of a rare phenomenon in female development (skewed X-inactivation), each sister's body processed the supplement's toxins differently: The Diagnosis: : Cuddy pressures House to find
liver couldn't break down the heavy metals, leading to pulmonary edema. Lea's neurological system took the hit, causing seizures.
had a delayed reaction that eventually triggered a cytokine storm. The Resolution
The title refers to a high-stakes medical mystery where Dr. Gregory House must solve a case involving a set of triplets whose identical DNA makes diagnosing their divergent symptoms a nightmare . The Case of the Mirror Triplets