Splenic lymphomas represent a heterogeneous group of rare B-cell neoplasms primarily involving the spleen, bone marrow, and often the peripheral blood. The most common subtype is Splenic Marginal Zone Lymphoma (SMZL). This paper reviews the clinical presentation, diagnostic criteria (histology and immunophenotype), and evolving therapeutic strategies for these malignancies. 1. Introduction
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Anemia or thrombocytopenia due to hypersplenism or bone marrow involvement. Splenic lymphomas represent a heterogeneous group of rare
Treatment is indicated only for symptomatic patients (progressive cytopenia or painful splenomegaly). diagnostic criteria (histology and immunophenotype)