Download — Hyperthermie Maligne Pptx

Malignant hyperthermia (MH), or hyperthermie maligne , is a life-threatening pharmacogenetic disorder triggered primarily by volatile anesthetic gases and the muscle relaxant succinylcholine. It results in a hypermetabolic crisis due to an uncontrolled release of calcium from skeletal muscle cells. While rare, affecting roughly 1 in 5,000 to 1 in 50,000 anesthesia cases, it requires immediate recognition and treatment with dantrolene to prevent fatal complications.

MH is usually inherited in an autosomal dominant pattern, often involving mutations in the gene. Malignant Hyperthermia