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EASL Clinical Practice Guidelines: Drug-induced liver injury

Drug-induced liver injury (DILI), commonly referred to in French medical literature as , involves liver inflammation triggered by exposure to medications, supplements, or herbal products. It is the leading cause of acute liver failure in Western countries and a major reason for withdrawing drugs from the market. 1. Classification and Mechanisms Download Dossier hepatites medicamenteuses pdf

Medical dossiers typically classify these injuries into two main mechanisms: The most frequently cited include: Occurs at therapeutic

Occurs predictably when a certain toxic threshold is reached. The most common example is Paracetamol (Acetaminophen) overdose. Common Offending Agents

Over 1,300 substances have been identified as potentially hepatotoxic. The most frequently cited include:

Occurs at therapeutic doses in susceptible individuals due to genetic factors or immune-mediated hypersensitivity. It is harder to predict and may appear weeks or months after starting a treatment. 2. Common Offending Agents